One-Pot Synthesis of 3-(Trimethylsilyl) propynamides

AS Medvedeva, MV Andreev, LP Safronova

Index: Medvedeva; Andreev; Safronova Russian Journal of Organic Chemistry, 2010 , vol. 46, # 10 p. 1466 - 1470

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Citation Number: 5

Abstract

Abstract A highly efficient one-pot procedure was developed for the synthesis of 3- trimethylsilylpropynamides by acylation of amines with trimethylsilylpropynoyl chloride generated in situ. Selective N-acylation and N, O-bis-acylation of ß-amino alcohols with formation of, respectively, N-(hydroxyalkyl) propynamides and 2-methyl-2-[3-(trimethylsilyl) propynoylamino] propyl 3-(trimethylsilyl) propynoate were accomplished with high yields.