Green One-Pot Synthesis of 2H-Pyrans Under Solvent-Free Conditions Catalyzed by Ethylenediammonium Diacetate

MJ Riveira, MP Mischne

Index: Riveira, Martin J.; Mischne, Mirta P. Synthetic Communications, 2013 , vol. 43, # 2 p. 208 - 220,13

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Citation Number: 7

Abstract

Ethylenediammonium diacetate readily catalyzes the Knoevenagel-type condensation between 1,3-dicarbonyl substrates and α,β-unsaturated aldehydes at room temperature under solvent-free conditions. This rapid, efficient, and convenient one-pot approach to the synthesis of 2H-pyrans stands as a significant advance over previously reported protocols. This environmentally friendly methodology has been successfully applied to the synthesis of biologically active ...