Tetrahedron

Parikh–Doering oxidation–dehydration–Ugi cyclization cascade in the development of lactams from formidoalkanols (3> chain length> 7)

IA Khan, AK Saxena

Index: Khan, Imran A.; Saxena, Anil K. Tetrahedron, 2012 , vol. 68, # 1 p. 294 - 299

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Citation Number: 8

Abstract

De novo incorporation of N-formylated aminols as strategic substrates in legendary Ugi cyclization. Lactamization of N-formido alkanols is accomplished by a novel Parikh–Doering oxidation–dehydration–Ugi cyclization cascade leading to the formation of lactams up to eight carbons (ring size; n= 1–4) in moderate yields using formidoaminol, substituted aniline, and aliphatic/aromatic carboxylic acid derivatives as starting materials.