A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase

…, M Kobayashi, K Shinozaki, S Yoshida, T Asami

Index: Han, Sun-Young; Kitahata, Nobutaka; Saito, Tamio; Kobayashi, Masatomo; Shinozaki, Kazuo; Yoshida, Shigeo; Asami, Tadao Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3033 - 3036

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Citation Number: 26

Abstract

9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy as inhibitors of NCED was examined. One of the synthesized compounds (20) was found to be an inhibitor of this enzyme, and inhibited ABA accumulation and stomatal closing, ...