A Highly Efficient Synthesis of Sulphonamide Derivatives in the Presence of N-Methyl-2-pyrrolidone

Y Tan, SJ Wang, YT Wang, BX Gao…

Index: Tan, Yong; Wang, Su Juan; Wang, Yi Ting; Gao, Bao Xiang; Ba, Xin Wu Synthetic Communications, 2010 , vol. 40, # 24 p. 3648 - 3653

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Abstract

The sulphonamide derivatives are synthesized by two component condensation of alkyl bromide and sodium arylsulphonamide using N-methyl-2-pyrrolidone (NMP) as a reaction medium. This method results in high yields without the formation of unwanted side products, and expanding substrate scopes.

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