Kumada–Tamao–Corriu coupling of heteroaromatic chlorides and aryl ethers catalyzed by (IPr) Ni (allyl) Cl

MJ Iglesias, A Prieto, MC Nicasio

Index: Iglesias, Maria Jose; Prieto, Auxiliadora; Nicasio, M. Carmen Organic Letters, 2012 , vol. 14, # 17 p. 4318 - 4321

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Citation Number: 54

Abstract

The complex (IPr) Ni (allyl) Cl (IPr= 1, 3-bis (2, 6-diisopropylphenyl) imidazolidene) catalyzes the cross-coupling reactions of heteroaromatic chlorides with aryl Grignard reagents. Catalyst loadings as low as 0.1 mol% have been used to afford the products in excellent yields. This nickel-based catalytic system also promotes the activation of the CAr– O bond of anisoles in the Kumada–Tamao–Corriu reaction under fairly mild conditions.