Amino acid nitrosation products as alkylating agents

MP García-Santos, E Calle…

Index: Garcia-Santos; Calle; Casado Journal of the American Chemical Society, 2001 , vol. 123, # 31 p. 7506 - 7510

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Citation Number: 41

Abstract

Nitrosation reactions of α-, β-, and γ-amino acids whose reaction products can act as alkylating agents of DNA were investigated. To approach in vivo conditions for the two-step mechanism (nitrosation and alkylation), nitrosation reactions were carried out in aqueous acid conditions (mimicking the conditions of the stomach lumen) while the alkylating potential of the nitrosation products was investigated at neutral pH, as in the stomach ...