An efficient copper catalyst for the formation of sulfones from sulfinic acid salts and aryl iodides

JM Baskin, Z Wang

Index: Baskin, Jeremy M.; Wang, Zhaoyin Organic Letters, 2002 , vol. 4, # 25 p. 4423 - 4425

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Citation Number: 122

Abstract

Aryl sulfones are important compounds in the practice of medicinal chemistry. The functional group is found in numerous drugs, including the recently developed selective COX-2 inhibitor Vioxx. 1 The common methods for preparing these sulfones include the oxidation of sulfides 2 or the sulfonylation of arenes using aryl sulfonyl halides or aryl sulfonic acids in the presence of a strong acid catalyst. 3 Though these methods are attractive for their simplicity, they ...