Novel silyl linkers for solid-phase synthesis

MM Meloni, RCD Brown, PD White, D Armour

Index: Meloni, Marco M.; Brown; White, Peter D.; Armour, Duncan Tetrahedron Letters, 2002 , vol. 43, # 34 p. 6023 - 6026

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Citation Number: 14

Abstract

The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1, 3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of 1° alcohols, 2° alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more ...