Mechanism of inactivation of. gamma.-aminobutyric acid aminotransferase by 4-amino-5-hexynoic acid (. gamma.-ethynyl GABA)

JR Burke, RB Silverman

Index: Burke; Silverman Journal of the American Chemical Society, 1991 , vol. 113, # 24 p. 9329 - 9340

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Citation Number: 28

Abstract

Abstract: y-Aminobutyric acid (GABA) aminotransferase is a pyridoxal phosphate (PLP) dependent enzyme that catalyzes the degradation of y-aminobutyric acid. The inactivation of GABA aminotransferase has been shown to be an important treatment for epilepsy. The mechanism of inactivation of GABA aminotransferase by y-ethynyl GABA, a mechanism- based inactivator of GABA aminotransferase that shows anticonvulsant activity in animal ...