Design and synthesis of 7H-pyrrolo [2, 3-d] pyrimidines as focal adhesion kinase inhibitors. Part 1

…, D Karanewsky, X Gu, V Zhou, Y Liu, O Ohmori…

Index: Choi, Ha-Soon; Wang, Zhicheng; Richmond, Wendy; He, Xiaohui; Yang, Kunyong; Jiang, Tao; Sim, Taebo; Karanewsky, Donald; Gu, Xiang-Ju; Zhou, Vicki; Liu, Yi; Ohmori, Osamu; Caldwell, Jeremy; Gray, Nathanael; He, Yun Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2173 - 2176

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Citation Number: 40

Abstract

A series of 2-amino-9-aryl-7H-pyrrolo [2, 3-d] pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo [2, 3-d] pyrimidines represent a new class of kinase inhibitors.

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