Tetrahedron letters

Transamination of fluorinated β-keto carboxylic esters. A biomimetic approach to β-polyfluoroalkyl-β-amino acids.

VA Soloshonok, AG Kirilenko, VP Kukhar, G Resnati

Index: Soloshonok, Vadim A.; Kirilenko, Alexander G.; Kukhar', Valery P.; Resnati, Giuseppe Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3621 - 3624

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Citation Number: 60

Abstract

Abstract The base-catalyzed isomerization of N-benzylimines (or enamines) of β- polyfluoroalkyl-β-ketocarboxylic esters cleanly affords the N-benzylidene derivatives of β- polyfluoro-β-aminocarboxylic esters which are hydrolyzed to corresponding amino acids in high overall yields.