Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers …

…, D Ramanitrahasimbola, P Rasoanaivo…

Index: Chouteau, Franck; Ramanitrahasimbola, David; Rasoanaivo, Philippe; Chibale, Kelly Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 3024 - 3028

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Citation Number: 15

Abstract

An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho- Substituted bromo and biphenyl ether compounds displayed the best activity from the series.