Organic letters

Exploring a benzyloxyaniline linker utilizing ceric ammonium nitrate (CAN) as a cleavage reagent: solid-phase synthesis of N-unsubstituted β-lactams and secondary …

KH Gordon, S Balasubramanian

Index: Gordon, Kirsteen H.; Balasubramanian, Shankar Organic Letters, 2001 , vol. 3, # 1 p. 53 - 56

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Citation Number: 48

Abstract

A novel benzyloxyaniline linker that uses ceric ammonium nitrate (CAN) as a cleavage reagent is described. Its application in the solid-phase synthesis of N-unsubstituted β- lactams and secondary amides furnishes compounds in moderate to excellent yield (45- 91%) and high purity (93-99%).

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