Tetrahedron

The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes

JM Montierth, DR DeMario, MJ Kurth, NE Schore

Index: Montierth, John M.; DeMario, Dierdre R.; Kurth, Mark J.; Schore, Neil E. Tetrahedron, 1998 , vol. 54, # 39 p. 11741 - 11748

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Citation Number: 70

Abstract

Cu (II)-catalyzed coupling of polymer-bound ω-haloalkyn-l-ols to terminal alkynes proceeds in moderate yield to give unsymmetrical diynes upon hydrolytic removal from the polymer. Formation of the symmetrical homocoupled byproduct is suppressed relative to conventional Cadiot-Chodkiewicz conditions in homogeneous solution.