Synthesis of 2, 2-dimethyl-1, 25-dihydroxyvitamin D 3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

…, A Kittaka, K Yamaoka, K Takeyama, S Kato…

Index: Fujishima, Toshie; Kittaka, Atsushi; Yamaoka, Kazuyoshi; Takeyama, Ken-Ichi; Kato, Shigeaki; Takayama, Hiroaki Organic and Biomolecular Chemistry, 2003 , vol. 1, # 11 p. 1863 - 1869

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Citation Number: 15

Abstract

Cholecalciferol, known as vitamin D 3 , is metabolized to afford the hormonally active form, 1α,25-dihydroxyvitamin D 3 (1), through 25-hydroxyvitamin D 3 . In addition to its classical role in calcium and phosphorus homeostasis, 1α,25-dihydroxyvitamin D 3 dominates the cell cycle in many malignant cells, regulating proliferation, differentiation and apoptosis. 1 The broad spectrum of biological activities of 1 is considered to be mediated by a ligand-inducible ...