Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity. Synthesis and α 1-and α 2-adrenergic activity of 3-phenyl-3- …

B Macchia, M Macchia, C Manera, E Martinotti…

Index: Macchia, B.; Macchia, M.; Manera, C.; Martinotti, E.; Nancetti, S.; et al. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 11 p. 869 - 880

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Citation Number: 9

Abstract

In order to contribute to the definition of the role played by the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity, certain 3-phenyl-3-piperidinols (PPOs, 4) and their corresponding desoxy 3-phenylpiperidine analogs (PPEs, 6) were synthesized and tested for their (α1-and α2-adrenergic activity by means of functional tests on isolated preparations. As regards the α1-adrenergic activity, the values of the activity ...