Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility

…, Y Han, H Zhang, D Zhang, T Awakawa…

Index: Yan, Yan; Chen, Jing; Zhang, Lihan; Zheng, Qingfei; Han, Ying; Zhang, Hua; Zhang, Daozhong; Awakawa, Takayoshi; Abe, Ikuro; Liu, Wen Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12308 - 12312 Angew. Chem., 2013 , vol. 125, # 47 p. 12534 - 12538

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Citation Number: 32

Abstract

The control of biological phenomena by natural products, which have co-evolved with their macromolecular receptors, results in their critical role in medicinal chemistry and chemical biology.[1] The generation of libraries of naturalproduct-like compounds is a major area of current interest in diversity-oriented synthesis, however, synthetic accessibility and efficiency of these compounds may face challenges associated with their structural complexity.[1] ...