A catalytic asymmetric chlorocyclization of unsaturated amides

A Jaganathan, A Garzan, DC Whitehead…

Index: Jaganathan, Arvind; Garzan, Atefeh; Whitehead, Daniel C.; Staples, Richard J.; Borhan, Babak Angewandte Chemie - International Edition, 2011 , vol. 50, # 11 p. 2593 - 2596

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Citation Number: 107

Abstract

Stereodefined carbon–halogen bonds are ubiquitous in nature with several natural products exhibiting this motif.[1] While the biogenetic origins of this unique chiral functionality has been a subject of several investigations in the past,[2] attempts by organic chemists to forge the carbon–halogen bond stereoselectively have largely been unsuccessful. This problem has come into focus only recently. Several elegant reports of asymmetric halogenations of ...

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