Journal of the American Chemical Society

Synthesis of Racemic, Optically Active and Radioactive α-Lipoic Acids

DS Acker, WJ Wayne

Index: Acker; Wayne Journal of the American Chemical Society, 1957 , vol. 79, p. 6483,6485

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Citation Number: 38

Abstract

We wish to report a convenient and versatile new synthetic route to a-lipoic acids. The alkylation of sodium disulfide to form the l,”-dithiolane ring has been described. I6 We have treated G, S-dichlorooctanoic acid and its esters8 with solutions of sodium disulfide to give a- lipoic acid and its esters, re~ pectively.~~ The sequence of reactions represented below permits the preparation of DL-a-lipoic acid,(+)-a-lipoic acid and DL-a-lipOiC acid-S235.