Chromone-Fused Cytosine Analogues: Synthesis, Biological Activity, and Structure–Activity Relationship

DD Haveliwala, NR Kamdar, PT Mistry…

Index: Haveliwala, Dhaval D.; Kamdar, Nimesh R.; Mistry, Prashant T.; Patel, Saurabh K. Nucleosides, Nucleotides and Nucleic Acids, 2014 , vol. 33, # 2 p. 80 - 91

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Citation Number: 4

Abstract

The preparation of a series of novel chromone-fused cytosine analogues, ie, chromeno [2, 3- d] pyrimidines has been carried out from substituted 2-amino-4-oxo-4H-chromene-3- carbonitriles with urea, thiourea, and guanidine under different reaction conditions. These chromone-fused cytosine analogues were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv strain and different microbial pathogenic strains in cell ...