Tetrahedron

Improved synthesis of tocopherol fatty alcohols and analogs: microglial activation modulators

T Muller, D Coowar, M Hanbali, P Heuschling, B Luu

Index: Muller, Thierry; Coowar, Djalil; Hanbali, Mazen; Heuschling, Paul; Luu, Bang Tetrahedron, 2006 , vol. 62, # 51 p. 12025 - 12040

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Citation Number: 11

Abstract

The synthesis of tocopherol fatty alcohols (TFAs), potent microglial activation modulators, was achieved via C-alkylation of trimethylhydroquinone. Several analogs, in particular water- soluble prodrugs, have been synthesized using a Wittig reaction and their antioxidant activities have been evaluated.

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