Rhodium-catalyzed 1, 4-addition of terminal alkynes to vinyl ketones

RV Lerum, JD Chisholm

Index: Lerum, Ronald V.; Chisholm, John D. Tetrahedron Letters, 2004 , vol. 45, # 35 p. 6591 - 6594

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Citation Number: 44

Abstract

The metal complex Rh (acac)(CO) 2 in the presence of an eqimolar amount of tris (o- methoxyphenyl) phosphine provides a useful catalyst system for the 1, 4-addition of alkynes to unsubstituted vinyl ketones. Best yields are obtained when the transformation is performed in benzene at reflux with an excess of vinyl ketone. Both aryl and alkyl substituted alkynes participate in the reaction. Primary alcohols and alkyl chlorides are well tolerated ...