The Effect of the Dynamics of Revolving Gates on the Kinetics of Molecular Encapsulation—The Activity/Selectivity Relationship

S Rieth, JD Badjić

Index: Rieth, Stephen; Badjic, Jovica D. Chemistry - A European Journal, 2011 , vol. 17, # 9 p. 2562 - 2565

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Citation Number: 16

Abstract

Transmembrane ion channels and intramolecular tunnels in enzymes employ different mechanisms to direct the trafficking of ions and small molecules.[1] In some instances, enzymes use rapidly fluctuating aromatic residues—gates for exerting the kinetic discrimination of differently sized substrates and their selective conversion into products.[2– 5] Thus, acetylcholine, a relatively small compound, is capable of effectively passing ...