Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase

LMV Tillekeratne, A Sherette, JA Fulmer, L Hupe…

Index: Tillekeratne; Sherette, Angela; Fulmer, Jennifer A; Hupe, Lynn; Hupe, Donald; Gabbara, Sam; Peliska, James A; Hudson, Richard A Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 4 p. 525 - 528

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Citation Number: 22

Abstract

A new class of inhibitors of HIV-1 reverse transcriptase obtained by the systematic structural simplification of epicatechin and epigallocatechin gallates are also shown here to inhibit DNA-strand-transfer, a process critical to the completion of the HIV-1-RT reproduction and ...

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