Structure—neuromuscular blocking activity relationships of ketophosphonium salts

R Houssin, JP Hénichart, M Foulon…

Index: Houssin; Henichart; Foulon; Baert Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 8 p. 888 - 891

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Abstract

Abstract Three ketophosphonium salts containing a morpholino group were prepared and evaluated for their neuromuscular blocking effect. Solution and crystal conformations were studied. An attempt was made to explain, in structural terms, different activity levels in connection with the interatomic distances.