Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and ureas. XVII. Synthesis of N-benzhydryl-N′-(heteroyl) …

LG Tignibidina, AA Bakibaev, VK Gorshkova…

Index: Tignibidina, L. G.; Bakibaev, A. A.; Gorshkova, V. K.; Saratikov, A. S.; Fomintseva, L. G. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 8 p. 547 - 549 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 8 p. 17 - 18

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Abstract

Previous studies [2, 3] have shown that benzhydrylureas have high anticonvulsive activity, and another report [4] showed that the introduction of aliphatic or aryl carboxyl radicals at the free nitrogen atom of monosubstituted ureas leads to a reduction in the biological activity of the original compound. With the aim of gaining further understanding of these relationships in benzhydrylurea derivatives substituted with heteroyl radicals, and to find new ...