Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate

…, MA Jakupec, VB Arion, N Metzler??Nolte…

Index: Meier, Samuel M.; Novak, Maria; Kandioller, Wolfgang; Jakupec, Michael A.; Arion, Vladimir B.; Metzler-Nolte, Nils; Keppler, Bernhard K.; Hartinger, Christian G. Chemistry - A European Journal, 2013 , vol. 19, # 28 p. 9297 - 9307

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Citation Number: 25

Abstract

Abstract Organometallic Ru (arene)–peptide bioconjugates with potent in vitro anticancer activity are rare. We have prepared a conjugate of a Ru (arene) complex with the neuropeptide [Leu 5]-enkephalin.[Chlorido (η 6-p-cymene)(5-oxo-κO-2-{(4-[(N-tyrosinyl- glycinyl-glycinyl-phenylalanyl-leucinyl-NH 2) propanamido]-1H-1, 2, 3-triazol-1-yl) methyl}- 4H-pyronato-κO) ruthenium (II)](8) shows antiproliferative activity in human ovarian ...