Mercapto heterocyclic carboxylic acids, analogs of 3-mercaptopicolinic acid

B Blank, NW DiTullio, FF Owings…

Index: Blank,B. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 572 - 576

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Citation Number: 19

Abstract

3-Mercaptopicolinic acid (3-MPA), a potent hypoglycemic agent in fasted rats, provided the impetus for substituting this compound with a 5-mercapto group (I), a 6-carboxyl group (21, and a 5-mercapto and 6-carboxyl group (3) and for replacing the pyridine ring with other heterocycles: quinoline (4), thiazole (51, pyrazine (6), isoquinoline (7), and indole (8). The methyl sulfoxide (9) and sulfone (10) of 3-MPA were also prepared. The new compounds ...