ChemMedChem

Synthesis of a heparan sulfate mimetic library targeting FGF and VEGF via click chemistry on a monosaccharide template

L Liu, C Li, S Cochran, S Jimmink, V Ferro

Index: Liu, Ligong; Li, Caiping; Cochran, Siska; Jimmink, Shane; Ferro, Vito ChemMedChem, 2012 , vol. 7, # 7 p. 1267 - 1275

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Citation Number: 9

Abstract

Abstract A disulfated methyl 6-azido-6-deoxy-α-D-mannopyranoside template was used as a core structure for binding to the angiogenic growth factors FGF-1, FGF-2, and VEGF. The core structure was diversified in a rapid, parallel manner by employing the Cu I-catalyzed Huisgen azide–alkyne cycloaddition (“click”) reaction. The diversity was further extended by incorporating a Swern oxidation–Wittig reaction sequence on a click adduct of propargyl ...