New synthesis of tic-hydantoins sigma-1 ligands and pharmacological evaluation on cocaine-induced stimulant effects

…, MA Debreu-Fontaine, T Maurice, P Melnyk

Index: Toussaint; Debreu-Fontaine; Maurice; Melnyk Medicinal Chemistry, 2010 , vol. 6, # 6 p. 355 - 373

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Citation Number: 6

Abstract

Activation of the newly identified 1 chaperone protein is involved in several aspects of the psychostimulant and addictive effects of cocaine. The development of ligands that selectively target the 1 protein may lead to putative potent anti-cocaine agents. We report here a new and more convergent synthetic pathway to amino side chain substituted hydantoins. Twenty new analogs of our lead compound were synthesized. None of them ...