The characterization of a novel V1b antagonist lead series

CA Smethurst, JA Borthwick, S Gaines…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 1 p. 92 - 96

Full Text: HTML

Citation Number: 4

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Replacement of the thiazole ring in 3 with alternative aryl rings was investigated using analogous chemistry to that described in Scheme 1. These replacements generally had similar or slightly lower potency than 3 (Table 2) and were ...