Organic letters

β-Amyrin Biosynthesis: The Critical Role of Steric Volume at C-19 of 2, 3-Oxidosqualene for Its Correct Folding To Generate the Pentacyclic Scaffold

T Hoshino, Y Yamaguchi, K Takahashi, R Ito

Index: Hoshino, Tsutomu; Chiba, Akifumi; Abe, Naomi Chemistry - A European Journal, 2012 , vol. 18, # 41 p. 13108 - 13116

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Citation Number: 4

Abstract

The effect of the steric volume at C-19 of (3 S)-2, 3-oxidosqualene 1 on the polycyclization reaction by β-amyrin synthase was examined. The substrate analogs, in which the methyl group at C-19 of 1 was substituted by an ethyl group and hydrogen atom, were converted