Tetrahedron letters

Expeditious enyne construction from alkynes via oxidative Pd (II)-catalyzed Heck-type coupling

V Hadi, KS Yoo, M Jeong, KW Jung

Index: Hadi, Victor; Yoo, Kyung Soo; Jeong, Min; Jung, Kyung Woon Tetrahedron Letters, 2009 , vol. 50, # 20 p. 2370 - 2373

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Citation Number: 21

Abstract

The enyne, ubiquitous in natural products, can be a challenge to generate since these moieties require many synthetic transformations to assemble them. We developed a simpler protocol to construct enynes while we found that this oxidative reaction was tolerant in substrate scope. In addition, the utility of this reaction was demonstrated through the attempt in synthesizing antifungal agent Lamisil™.

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