Synthesis of 2-chloro-3-oxoesters by reaction of the dianion of ethyl 2-chloroacetoacetate with electrophiles

V Specowius, T Rahn, M Adeel, S Reim, H Feist…

Index: Specowius, Verena; Rahn, Thomas; Adeel, Muhammad; Reim, Stefanie; Feist, Holger; Saghyan, Ashot S.; Langer, Peter Monatshefte fur Chemie, 2013 , vol. 144, # 5 p. 627 - 631

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Abstract

Chlorinated arenes and hetarenes occur in a number of natural products and are lead structures in medicinal chemistry (examples of pharmacologically active chlorinated natural products and drugs include griseofulvin [1–7] and dihydronidulin [8]). In fact, in many cases, they show better pharmacological activities than their chloride-free derivatives (for an example from our laboratory, see [9, 10]). Chloroarenes and chlorohetarenes are building blocks in ...