European journal of organic chemistry

Synthesis and Intramolecular Aldol Reactions of 1, 6??and 1, 7??Bis (acylsilanes)

JP Bouillon, C Portella

Index: Bouillon, Jean-Philippe; Portella, Charles European Journal of Organic Chemistry, 1999 , # 7 p. 1571 - 1580

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Citation Number: 22

Abstract

Abstract A series of 1, 6-and 1, 7-bis (acylsilanes) have been prepared using a strategy of substitution of dihalo derivatives with a synthetic equivalent of the trialkylsilylcarbonyl anion. These bis (acylsilanes) could easily be converted, under Lewis acid activation, into cis-β- hydroxyacylsilanes or the corresponding α, β-unsaturated derivatives, by means of a completely stereoselective intramolecular aldol reaction.