Synthesis and mode of action of 125I-and 3H-labeled thieno [2, 3-c] pyridine antagonists of cell adhesion molecule expression

…, V Schaefer, SA Boyd, GF Okasinski

Index: Zhu, Gui-Dong; Schaefer, Verlyn; Boyd, Steven A.; Okasinski, Gregory F. Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 943 - 948

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Citation Number: 21

Abstract

A series of thieno [2, 3-c] pyridine antagonists of cell adhesion molecule (CAM) expression, such as A-205804 (1) and A-249377 (2), selectively suppressed the induced expression of E- selectin and ICAM-1 over VCAM-1. In an effort to explore the biological mechanism of action of these inhibitors, we synthesized 125I-and 3H-labeled thieno [2, 3-c] pyridines 5 and 6. An isolated diazonium tetrafluoroborate salt efficiently trapped Na125I on very small scale ( ...