Synthesis of a sialyl lewisX mimetic conjugated with DTPA, potential ligand of new contrast agents for medical imaging

Y Fu, S Laurent, RN Muller

Index: Fu, Yanjun; Laurent, Sophie; Muller, Robert N. European Journal of Organic Chemistry, 2002 , # 23 p. 3966 - 3973

Full Text: HTML

Citation Number: 33

Abstract

Abstract The structure of a mimetic of sialyl Lewis X, namely 3-[2-(α-D-mannopyranosyloxy) phenyl] phenylacetic acid, was coupled to diethylenetriaminepentaacetic acid (DTPA) via a flexible alkyl spacer and the amide linkage. The overall yield of the eleven-step synthesis starting from 3-bromophenylacetic acid was 4− 8%. This new ligand is expected to target inflammation sites through specific interactions with selectins, the adhesion molecules ...

Related Articles:

Synthesis of Phenylboronic Acids in Continuous Flow by Means of a Multijet Oscillating Disc Reactor System Operating at Cryogenic Temperatures

[Sleveland, Dagfinn; Bjorsvik, Hans-Rene Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1121 - 1130]

Boronic ester as a linker system for solid phase synthesis

[Carboni, Bertrand; Pourbaix, Christelle; Carreaux, Francois; Deleuze, Herve; Maillard, Bernard Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7979 - 7983]

Borylation using group IV metallocene under mild conditions

[Marciasini, Ludovic D.; Vaultier, Michel; Pucheault, Mathieu Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1702 - 1705]

More Articles...