Synthesis of Phenylboronic Acids in Continuous Flow by Means of a Multijet Oscillating Disc Reactor System Operating at Cryogenic Temperatures

D Sleveland, HR Bjørsvik

Index: Sleveland, Dagfinn; Bjorsvik, Hans-Rene Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1121 - 1130

Full Text: HTML

Citation Number: 14

Abstract

A multijet oscillating disk (MJOD) millireactor system suitable for operating at cryogenic temperatures has been developed, assembled, and investigated. This new reactor system (cryoMJOD) was realized with the purpose to prepare various phenylboronic acids in a continuous two (three)-step telescoped synthetic process at temperatures in the interval− 50 to− 75° C. In this process, n-butyllithium was reacted with a phenylbromide to provide the ...

Related Articles:

Synthesis of a sialyl lewisX mimetic conjugated with DTPA, potential ligand of new contrast agents for medical imaging

[Fu, Yanjun; Laurent, Sophie; Muller, Robert N. European Journal of Organic Chemistry, 2002 , # 23 p. 3966 - 3973]

Boronic ester as a linker system for solid phase synthesis

[Carboni, Bertrand; Pourbaix, Christelle; Carreaux, Francois; Deleuze, Herve; Maillard, Bernard Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7979 - 7983]

Borylation using group IV metallocene under mild conditions

[Marciasini, Ludovic D.; Vaultier, Michel; Pucheault, Mathieu Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1702 - 1705]

More Articles...