Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans

KC Nicolaou, JA Pfefferkorn, AJ Roecker…

Index: Nicolaou; Roecker; Pfefferkorn, Jeffrey A.; Cao, Gou-Qiang Journal of the American Chemical Society, 2000 , vol. 122, # 12 p. 2966 - 2967

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Citation Number: 617

Abstract

Herein we report a novel strategy for the design and construction of natural and natural product-like libraries based on the principle of privileged structures, a term originally introduced to describe structural motifs capable of interacting with a variety of unrelated molecular targets. The identification of such privileged structures in natural products is discussed, and subsequently the 2, 2-dimethylbenzopyran moiety is selected as an ...