Tetrahedron letters

N-Methylpyrrolidin-2-one hydrotribromide (MPHT) a mild reagent for selective bromination of carbonyl compounds: synthesis of substituted 2-bromo-1-naphtols

A Bekaert, O Provot, O Rasolojaona, M Alami…

Index: Bekaert, Alain; Provot, Olivier; Rasolojaona, Olimihamina; Alami, Mouad; Brion, Jean-Daniel Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4187 - 4191

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Citation Number: 47

Abstract

The reaction of the N-methylpyrrolidin-2-one hydrotribromide complex (MPHT) with substituted-1-tetralones has been investigated. This safety reagent proved to be successful for selective α, α-dibromination of tetralones. Moreover, under base-free conditions, several 2-bromo-1-naphtols were obtained from tetralones in a 'one pot'sequence in good to excellent yields.

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