Structure/activity relationships in lysophosphatidic acid: the 2-hydroxyl moiety

…, SJ Carlisle, JG Catalano, M Zhang, TL Macdonald

Index: Lynch, Kevin R.; Hopper, Darrin W.; Carlisle, Steven J.; Catalano, John G.; Zhang, Ming; Macdonald, Timothy L. Molecular Pharmacology, 1997 , vol. 52, # 1 p. 75 - 81

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Citation Number: 42

Abstract

Abstract Although lipid phosphoric acid mediators such as lysophosphatidic acid (LPA) are now recognized widely as intercellular signaling molecules, the medicinal chemistry of these mediators is poorly developed. With the goal of achieving a better understanding of the structure activity relationships in LPA, we have synthesized and tested a series of LPA analogs that lack the 2-hydroxyl moiety. Our series consisted of compounds with 2, 3, or 4 ...