Gold??Catalyzed Oxidative Cycloadditions to Activate a Quinoline Framework

DB Huple, S Ghorpade, RS Liu

Index: Huple, Deepak B.; Ghorpade, Satish; Liu, Rai-Shung Chemistry - A European Journal, 2013 , vol. 19, # 39 p. 12965 - 12969

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Citation Number: 21

Abstract

One advent in gold catalysis is to generate α-oxo gold carbenes [1] by an intermolecular oxidation of terminal alkynes by using pyridine-based oxide derivatives [2, 3] with 8- alkylquinoline oxide (Z+ÀOÀ) being the most effective.[3] Besides easy and safe operation, gold carbenes generated in this method might exhibit chemoselectivity [3e, i] distinct from other metal carbenes produced from hazardous α-diazo carbonyl reagents.[4] Importantly, ...