Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution

J Yoo, DE Reichert, MJ Welch

Index: Yoo, Jeongsoo; Reichert, David E.; Welch, Michael J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6625 - 6637

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Citation Number: 42

Abstract

The in vivo behavior of copper (II)-cyclen complexes was modified via substitution of the parent ligand with two different substituents, 4-tert-butylbenzyl and acetate. This was achieved by using same synthetic strategy (regioselective protection/first alkylation/deprotection/second alkylation) to give nine cyclen derivatives. The X-ray structure of [Cu (2c) Cl]+(2c= 1-(4-tert-butylbenzyl)-1, 4, 7, 10-tetraazacyclododecane) showed that ...