Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors

CA Mooney, SA Johnson, P 't Hart…

Index: Flemer, Stevenson; Wurthmann, Alexander; Mamai, Ahmed; Madalengoitia, Jose S. Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7593 - 7602

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Citation Number: 13

Abstract

... Journal of Medicinal ... J. Med. ... bearing exocyclic substituents capable of occupying the so-called “150-cavity” adjacent to the active site of certain neuraminidase subtypes (N1, N4, and N8).(18) Recently, the groups of Pinto and Cairo employed click chemistry based strategies to ...