A Convenient Synthesis of the Echinacea??Derived Immunostimulator and HIV??1 Integrase Inhibitor (−)??(2R, 3R)??Chicoric Acid

…, L Pouységu, C Delattre, S Quideau…

Index: Lamidey, Anne-Marie; Fernon, Lionel; Pouysegu, Laurent; Delattre, Charlotte; Quideau, Stephane; Pardon, Patrick Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2328 - 2334

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Citation Number: 29

Abstract

Abstract The Echinacea-derived immunostimulator and HIV-1 integrase inhibitor (−)-chicoric acid (= 2, 3-bis {[3-(3, 4-dihydroxyphenyl)-1-oxoprop-2-enyl] oxy} butanedioic acid; 1a) was conveniently prepared via a silane-promoted Pd-mediated chemoselective hydrogenolysis of its perbenzylated derivative 12a, which was generated from an efficient and reliable carbodiimide-mediated coupling reaction between the caffeic acid dibenzyl ether ...