Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo [b] thiophene 1, 1-dioxide sulfonamides

A Innocenti, R Villar, V Martinez-Merino, MJ Gil…

Index: Innocenti, Alessio; Villar, Raquel; Martinez-Merino, Victor; Gil, Maria J.; Scozzafava, Andrea; Vullo, Daniela; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4872 - 4876

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Citation Number: 34

Abstract

A series of selected benzo [b] thiophene-5-and 6-sulfonamide derivatives previously reported to show cytotoxic activity and some others newly synthesized has been tested for the interactions with several CA isozymes, some of which are known to be involved in tumorigenesis (hCA IX), whereas others are ubiquitously found in many normal tissues (the cytosolic isoforms hCA I and II). The unsubstituted sulfonamides inhibited hCA I with ...

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