New synthesis of 3-substituted indazoles from 3-trimethylsilylindazole

Y Hari, Y Shoji, T Aoyama

Index: Hari, Yoshiyuki; Shoji, Yoshimichi; Aoyama, Toyohiko Synthesis, 2004 , # 8 p. 1183 - 1186

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Citation Number: 11

Abstract

Quite recently, we have reported the [3+2] cycloaddition reaction of lithium trimethylsilyldiazomethane [TMSC(Li)N 2 ] and benzynes in situ generated from halobenzenes to give 3-trimethylsilylindazoles bearing various substitutents on the benzene ring. [7] As an extension of this work, we investigated a conversion of 3-trimethylsilylindazole into 3-substituted indazoles by reaction with electrophiles in order to examine the utility of 3-trimethylsilylindazoles as the synthetic intermediate and ...