Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: A general and flexible route to 3-arylindazoles

V Collot, P Dallemagne, PR Bovy, S Rault

Index: Collot, Valerie; Dallemagne, Patrick; Bovy, Philippe R.; Rault, Sylvain Tetrahedron, 1999 , vol. 55, # 22 p. 6917 - 6922

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Citation Number: 95

Abstract

This paper describes a Suzuki Type cross coupling reaction of 3-iodoindazoles with aryl and heteroaryl boronic acids as a general route to 3-arylindazoles. The coupling reaction is illustrated by the preparation of new aryl-or heteroarylindazoles 7. Scope and limitation of the method are outlined. The coupling reaction works best on a 1-substituted indazole nucleus. The usefulness of the reaction is illustrated by a short practical synthesis of YC-1, ...