2-Aryl (pyrrolidin-4-yl) acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

…, JA Milligan, GJ Shei, G Chrebet, J Bergstrom…

Index: Yan, Lin; Budhu, Richard; Huo, Pei; Lynch, Christopher L.; Hale, Jeffrey J.; Mills, Sander G.; Hajdu, Richard; Keohane, Carol A.; Rosenbach, Mark J.; Milligan, James A.; Shei, Gan-Ju; Chrebet, Gary; Bergstrom, James; Card, Deborah; Mandala, Suzanne M. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3564 - 3568

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Citation Number: 19

Abstract

A series of 2-aryl (pyrrolidin-4-yl) acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rat.